Toxicology Risk Assessment

If you have identified an extractable/leachable chemical in your medical device, drug, cosmetics, consumer product, or food packaging material, 2SD TS offers the expertise of American Board of Toxicology (ABT) diplomates to evaluate the chemical. Our consultants have extensive experience with both commercial and open source (Q)SAR analysis programs, such as the commercial software Leadscope and the OECD Toolbox.

Apply cheminformatics approach (e.g., chemical functional group identification, structure/activity, similarity search) to characterize the molecule and predict physicochemical properties, ADME and environmental fate, and toxicity.

Data filling and read across for biological endpoints (cytotoxicity, sensitization, genotoxicity) 

Calculation of daily intake, allowable limits, exposure limits, and margin of safety following oral, inhalation or dermal exposure

Physiologically based pharmacokinetic modelling (PBPK) modelling of dietary chemical contaminants for exposure assessment for general population, placental transfer and newborn exposure calculation

Chemical hazard leveling, PBT (persistent, bioaccumulative and toxic) assessment

Material safety data sheet (MSDS) preparation

Chemical risk characterization and mitigation approaches